IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-4-15073 Original Research Paper The effect of Transdermal Tulobuterol patch in the treatment of Pediatric Asthma. Shivpuri Dr. April 2018 7 4 01 02 ABSTRACT

In this prospective, longitudinal, observational study100children between 5–18 years of age  with partially controlled or uncontrolled asthma as per GINA 2016 guidelines were taken up for the study. This study was conducted at the department of Pediatrics, Fortis Escorts Hospital, Jaipur between November 2016 and June2017. Of the 100 children 43% were partially controlled and 57% uncontrolled. The Tulobuterol transdermal patch was applied once daily at bedtime, in a dose of 1 mg for children 5 to <9 years and 2 mg for children ≥9 years of age. Controller therapy being given earlier was continued. Baseline Peak expiratory flow (PEF) was measured and repeated at 2 and 4 weeks after initiation of treatment.Baseline mean PEF was 138.35 ml which increased to 175.11 ml and 185.84 ml after 2 and 4 weeks respectively (p value <0.001).  After 4 weeks of Tulobuterol add on therapy, 85 % children had well controlled asthma as compared to baseline (p value<0.001).