Sclerosing agents such as polidocanol are widely used for treating varices and vascular malformations. Sclerotherapy hasbeenadvocated to target neovascularity that is often present in tendinopathy. Objective: To assess whether sclerotherapy, an injection–based therapy, improves elbow pain in patients with lateral epicondylosis. Methods:Inthisstudy,18patients(22 elbows) (10 menand8women,mean age40years)withthediagnosisof lateral epicondylosiswereincluded.Allpatientshada chronichistoryofpain(mean18months).Allpatients weretreatedwitha single injectionofthe sclerosingagentpolidocanol.Results:At6–months follow–uppost–injection, therewasagoodclinicalresultin17 out of 22elbows.Extensororiginpainduringwristloadingactivities wassignificantlyreduced.Conclusion: Sclerotherapy with polidocanol was well tolerated, effectively decreased extensor origin pain and improved elbow function in patients with refractory lateral epicondylosis.