Background –  In the present study , practice of spinal anaesthesia, Bupivacaine is the most commonly used drug for spinal anaesthesia. To improve the quality of surgical anaesthesia and providing post operative analgesia, adjuvants like clonidine and fentanyl are used.

Objective –To evaluate the efficacy of spinal anaesthesia with Clonidine and Fentanyl added to hyperbaric Bupivacainein abdominal and vaginal hysterectomies.

Methodology – 70 adult ASA 1 and ASA II patients of ages ranging between 30–60 years were included in the study who underwent elective hysterectomies.

They were divided into 2 groups

Group C– 2.5 ml( 12.5 mg) of 0.5%hyperbaric Bupivacaine + 50μgclonidineintrathecally – 35 cases

Group F –2.5ml(12.5 mg) of 0.5%hyperbaric Bupivacaine + 25μgfentanylintrathecally – 35 cases

Results  –IntrathecalClonidine with 0.5% hyperbaric Bupivacaine provided better quality of surgical anaesthesia and post operative analgesia without significant increase in side effects compared to intrathecalFentanyl with 0.5%hyperbaric Bupivacaine.

Conclusion – It can be concluded by the present comparative and statistically significant results that the combination of Bupivacaine 0.5% and Clonidine 50μg better  compared to Bupivacaine 0.5% and Fentanyl 25μg is better in providing surgical anaesthesia and prolonged post operative analgesia with no significant hemodynamic and respiratory side effects.