Coronary artery anomalies prevail in around 0.64–5.6% of patients undergoing coronary angiography. Percutaneous coronary intervention (PCI)is considered as the preferred treatment for patients over the age of 30 years with such anomalies. Here, we report a case of a 62–year–old diabetic woman, with a history of PCI to the anomalous right coronary artery (RCA) originating from the left aortic sinus, angiographically diagnosed with 99% re–stenosis in mid RCA.Drug eluting stents (DES) were successfully implanted into the diseased vessels and the patient is asymptomatic at 6 month follow–up.