Backgound: Laryngoscopy and endotracheal intubation are very essential tools in the hands of anaesthesiologists in maintaining the airway.They are associated with rise in heart rate and blood pressure .Many strategies have been advocated to attenuate the hemodynamic response to laryngoscopy and endotracheal intubation. Dexmedetomidine, a centrally acting alpha 2 agonist, provides anxiolysis and cooperative sedation without respiratoy depression.Esmolol a cardioselectivebetablocker,with no significant intrinsic sympathomimetic acticity,produces reduction in heartrate and bloodpressure.

Objective:To study the efficacy of i.vDexmedetomidine and i.vesmolol in attenuating the pressorresponse during laryngoscopy and intubation.

Methodology:60 Adult ASA 1 and ASA 2 point of both sexes and age between 20–50 years were included in the study .

They were divided into two groups:

Group D–1mcg/kg of Dexmedetomidine diluted in 100ml 0.9%NS over 10 min given 10 min before induction.

Group E–1.5mg/kg ofEsmolol diluted in 10ml NS given 2 min before induction of anaesthesia.

Results:

Dexmedetomidine 1mcg/kg is a better alternative for suppressingpressor response to laryngoscopy and endotracheal intubation in patients posted for elective surgery under general anaesthesia.

Dexmedetomidine was not associated with cardiovascular side effects like  change in heartrate and rhythm,respiratory depression and was a  better alternative to Esmolol in suppressing pressor response.

Conclusion: It can be concluded by the present comparative and statistically significant results that Dexmedetomidine is a better alternative to Esmololfor suppressing pressor response to laryngoscopy and endotracheal intubation in patients posted for elective surgery under general anaesthesia.