IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-4-15096 Original Research Paper Is there a role of estimation of serum lipid profile level in meibomian gland dysfunction? Gottumukkala Sridevi Dr. Dr. V. Narasinga Rao Dr. April 2018 7 4 01 02 ABSTRACT

 Aim: To determine any association between meibomian gland disease and fasting serum lipid profile level.

Setting: Hospital based study
Patients and methods: A case control study of 100 patients (cases) with symptoms and signs of Meibomian gland disease (MGD) and 100
patients (controls) without any symptoms of MGD, between November 2014 to September 2016. Investigations such as Tear film break up time
(TBUT), Schirmer‘s test, fluorescein and rose bengal staining for the eye along with fasting lipid profile was performed for all the patients. Study
groups both cases and controls were compared using Chi square test using SPSS 20.0 software (SPSS Inc., Chicago, IL, USA).
Results: Statistically significant elevation of total cholesterol (P=0.00), triglycerides (P=0.00) and LDL levels (P=0.046) were found in MGD
cases.
Conclusion: Patients with MGD with no history of hypercholesterolemia may have higher blood cholesterol levels (P=0.00) and triglycerides
levels (P=0.00) and LDL levels (P=0.046) than controls of similar age without MGD. If this finding is confirmed by larger studies, MGD may
become a marker of previously unknown hypercholesterolemia.