Background:The incidence of hypertension (HTN) has been increasing worldwide. Hypertension is associated with significant cognitive and psychomotor effects and anti–HTN themselves are reported to cause cognitive and psychomotor impairment in few studies. Effects of anti–HTNs are however controversial due to conflicting results of various studies. Objective:This study is planned to explore whether antihypertensive medication has a significant influence on cognitive and psychomotor performance in hypertensive patients.

Methods: In this cross sectional observational study hypertensives (25–50 yrs) of either sex were included. Patients were grouped into control (freshly diagnosed HTNs) and test groups 1 (Anti–HTNs <6 month)and 2 (Anti–HTNs >6 month). The effectsof anti–HTNs on cognitive and psychomotor performance were assessed using DSST, TMT &WMS tests; and compared amongst the groups. Data obtained was analyzed using student’s‘t’–test of OpenEpi statistical software. Results: Study clearly revealed that anti–HTNs themselves exhibit significant impairment incognitive and psychomotor performance; DSST (p<0.01),TMT(p<0.05) andWMS (p<0.05) when compared to group 1and control. Conclusions: Though Anti–HTNs are lifesaving drugs in HTNs it is noteworthy revelation that they impair cognitive and psychomotor performance of the patients, hence further studies to ascribe this effect to specific anti–HTN class is essential.