Objective: The current study has undertaken to explore the role of uric acid as a biomarker for insulin resistance in type 2 diabetic mellitus.

Material and Method: The study was conducted on 100 subjects of type 2 diabetic patients in Meerut District. Serum uric acid, Fasting plasma glucose, fasting plasma insulin and HOMA– IR were analyzed.

Result:  The study showed that there were significantly increased Serum Uric acid, Fasting Plasma Glucose, Fasting Serum Insulin and HOMA–IR values in T2DM subjects as compared to controls (p < 0.0001).

Conclusion: There is convincing evidence that there were significant correlation between uric acid and HOMA–IR value. Hyperuricemia is related to  risk factors for insulin resistance in type 2 diabetes. The study concluded a significant progressive relationship between increased uric acid level with respect to HOMA–IR levels which is an indices of insulin resistance.