AIM:To study the clinical profile of H1N1 positive patients admitted in Swine flu ward in NSCB Medical College, Jabalpur in outbreak of 2015.

MATERIALS & METHODS: All H1N1 positive patients admitted in NSCB MCH, Jabalpur were analysed retrospectively with respect to morbidity and mortality and possible clinical conclusions were derived.

RESULTS:Of 64 H1N1 positive patients, 23 died. Cough, fever & dyspnoea were main symptoms in all patients including those under mortality group. Those with a duration of stay in hospital >10 days had least mortality. Highest mortality seen in patients with duration of stay between 1–10 days.  40 (62.5%) of 64 patients had some co–existing illness of which Anemia & DM were most common. 16 (69.5%) out of 23 patients who died had some co–existing illness of which DM was associated with 9 patients, Anaemia with 8 & Hypertension with 7 patients. 25 (39%) of 64 patients developed some complications of which ARDS & encephalopathy had higher mortality as compared to Renal failure & MODS. Of 23 patients who died, 18 (78%) developed some complication.

CONCLUSION:Knowing the potential of Influenza virus for genetic mutations, it is difficult to find a stereotype pattern of illness as also documented by studies done in past. Good clinical skills always carry high value in suspecting & defining H1N1 infection & its complications. Co–existing illness must be taken special care of during an outbreak of Swine flu. Community education, timely immunization of those at high risk & early referral can save many lives.