Aim: To estimatethe prevalence of inhibitors in hemophilia A and B.

Material and methods:Out of 81 haemophilia patients screened, 73 (90%) had haemophilia A and 8 (10%) had haemophilia B. The age range of patients with haemophilia A was 7–46 years (mean age, 19.19 years) and that of haemophilia B was 8–20years (mean age=13 years). Most patients presented with hemarthroses.. Bethesda assay was performed to quantify the inhibitors in these haemophilia A patients [Table 2].

Results:Twelve patients (16%) of haemophilia A were positive on inhibitor screening using the mixing study which is comparable to other studies in IndiaOnly two patients showed high titre levels (>256 BU/ml). None of Haemophilia B patients tested positive for inhibitors. In this study all the patients who developed inhibitors had severe hemophiliaA .

Conclusion:Further studies are required in our country to derive a robust set of data regarding prevalence of inhibitors in haemophilia patients so that appropriate treatment protocols can be institutionalised.