IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-5-15226 Original Research Paper Assesment of airway inflammation in Bronchiectasis Dr. May 2018 7 5 01 02 ABSTRACT

 INTRODUCTION: In Bronchiectasis initial colonization of the lower respiratory tract by different microorganisms as the first step leading to

inflammatory response characterized by neutrophil migration within the airways and secondary secretion of variety of tissue damaging oxidants
and enzymes such as neutrophil elastase, myeloperoxidase and cytokines [interleukins] . Persistence of microorganisms in the airways because of
impairment in mucus clearance may lead to a vicious circle of events characterized by chronic bacterial colonization, persistent inflammatory
reaction and progressive tissue damage and morbidity life.
In order to evaluate the level of bronchial inflammation in relation with bacterial colonisation; we did bronchoalveolor lavage of patients admitted
with HRCT Chest[taken within 3 months] evidence of bronchiectasis and fulfill with inclusion criteria of study. The obtained sample was
centrifuged and stored in 2 to 8‘C temperature for IL–8 estimation
METHOD OF STUDY: Continuous prospective study
RESULTS: Among 90 study population analysis showed females were 58% and males were 42%. Cylindrical bronchiectasis 53%, followed by
cystic bronchiectasis36% in predominance: and positive culture growth rate for sputum samples were 68% and BAL samples were 77%. Regarding
airway inflammation, the total counts of BAL fluid were increased in all the patients with slight higher level in positive culture growth patients with
slight Neutrophilic predominance. [90–210X10*3 cells in range and 120x10*3 cells in median]. The IL–8 measured showed increased level in all
three groups comparing control groups indicating earlier establishment of inflammation in bronchiectasis. [81–835pg/dl in range and 556pg/dl in
median]