Nephrotic syndrome (Kidney injury) is complex disease which impairs the kidney functions dramatically. The classical features of Nephrotic syndrome are excessive  loss of proteins through urine, Hyper cholesterolemia, Hyperlipidemia, Hypo abluminemia and edema. The exact underlying  pathology (etiology) of this disease is not clear, however this is thought to be due to damage in kidney filtering units that is injury to podocyte or damage  to Glomerular basement membrane(GBM). The condition exists as a Chronic or Acute based on the degree of kidney injury. Since the exact etiology of the disease  is not  well understood the management of the diseaseposes great challenge to medical field. It affects both the sexes and in all age groups. As the disease progresses further it leads to End stage renal disease(ESRD) where Dialysis or kidney transplant are the choiceof management. My research revealed that this disease is caused  by one specific “PATHOGEN”which remains “Hidden throughout the course of the disease. The “PATHOGEN” can be identified by specific simple and economic technology developed by me. If this “PATHOGEN” is targeted TOTAL CURE of this condition is possible.