IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-5-15260 Original Research Paper CLINICOPATHOLOGICAL PROFILE OF HORMONE POSITIVE BREAST CANCER. SUMITA A. JAIN Dr. May 2018 7 5 01 02 ABSTRACT

 Aim

The aim of this study was to determine the correlation of expression of Hormone receptors with various pathological parameters like tumour size,
tumour grade, age of the patient at the time of presentation of disease in Northern part of INDIA.
Background:
Molecular classification of breast cancer is based on gene expressing profile.
They subgroup [luminal A, luminal B, HER2, and basal like] have distinct gene expression pattern and phenotypical characteristics.
Hormone positive shares phenotypical features with luminal like breast cancer, which is in turn the less aggressive and with good outcome.
They are associated with Good responsive to endocrine therapy and short survival.
Material And Method:
Hospital based retrospective, descriptive type of observational study.Study place: Dept. of general surgery SMS hospital Study Design: Jaipur.
Study population: 402 cases of diagnosed breast cancer.
Statistical Analysis: Descriptive statistics.
Result:
Total breast cancer patients studied = 402. Among total cases 115 were luminal type A
· In less than 40 years old cases 33.3% are ER/PR positive and in > 50 years old cases 75.0% are ER/PR positive.
· In our study 80% cases were ER/PR positive in tumor less than 2 cm compared to 42.11% in tumor size more than 5 cm .
· The left sided breast is more commonly involved (60.0%) to right (40.0%) in our study.
· The upper outer quadrant was most commonly involved (69.5%) in our study.
· Painless lump was more common in all ER/PR +ve (77.2%)
· In our study 87.5 % cases were in grade I tumor .
· 70.6% cases were ER/PR positive in negative axillary lymph node tumour
Conclusions:
1. Painless lump is commonest complaint in ER/PR +ve
2 .The left sided breast is more commonly involved (60.0%) to right (40.0%) in our study.
3 . The upper outer quadrant was most commonly involved (69.5%).
4. Younger patient were less likely to be ER/PR positive as compared to older patients.
5. Patient with lower tumour grade were more likely to be ER/PR positive as compared to patients with high grade tumour.
6. Patient with lower tumor size was more likely to be ER/PR positive as compared to patient with large tumor size.
7. ER/PR positive patient have less number of positive nodes