IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-5-15270 Original Research Paper Spectrum of cutaneous metastasis from internal malignancies : A study of clinico-pathological and survival evaluation of 126 patients Veenita Yogi Dr. Dr.Manish Ahirwar Dr. May 2018 7 5 01 02 ABSTRACT

Cutaneous metastasis (CM) from internal malignancy are relatively uncommon and accounts for 0.7% to 9%. CM may herald the diagnosis of internal malignancy, and early recognition can lead to accurate and prompt diagnosis and timely treatment .The most common cancer metastasizing to the skin are breast , lung, colorectal and melanoma.

 

Material and Methods: This  retrospective study analyzed  126 patients of CM registered in the department  between year 2007 to 2016.All the patients were histopathologically  proven  primary and cutaneous lesions. CM were analyzed on the basis of type and site of presentation, other distant visceral and skeletal  metastasis, time interval between primary malignancy and development of cutaneous metastasis and survival.

 

Results:This study included  50 males (39.6 %)  and 76 females (60.3 % ) with a median age of  46.5 years  ( range 16–80 years). The presence  of CM  in different body sites  were  abdomen  (49.2 %) , chest  (44.4 %), extremities ( 17.4 %), face (15.8 %),  back  (12.6 %), surgical scar (12.6 %), scalp (11 %),inguinal region (8 %), and breast (6.3 %). Eighty two percent of the patients were presented with nodular lesions.CM was the first sign of internal malignancy in 14 patients  from different malignancies.Thirty patients presented with CM on  surgical scar  from different primary malignancies.Fourpatients presented with metastasis  in female breast .Scalp metastasis was exhibited in 21 patients .The survival of the patients after recognition of the cutaneous metastasis ranged  from one to 46 months , depending on tumor type. Overall mean survival time was 13.54 (11.5–15.6) months. Overall survival comparison using log rank hypothesis was done with chi–square statistic value of 14.673 ( p–0.023) with 95% confidence limit.

 

Conclusion:  CM are important to recognize early, they often dramatically alters treatment plan. The appearance of these cutaneous metastasis signals widespread distant and systemic metastatic internal malignancy, resulting in poor outcome and patient survival.