Nanotechnology is a new transnational and transcultural development that is growing rapidly and pervasively. The potential impact of novel Nanodentistry Applications in disease diagnosis, therapy and prevention is foreseen to change oral health care in a fundamental way. This review presents a general overview of the novel nanomaterial and relevant advances of nanotechnology, focusing on promising dental applications. With the application of nanotechnology, the composition of dental implants, surface energy and roughness and topography can be improved for better osseointegration and it can also influence the events occurring at the bone–implant interface. The cellular activities and tissue responses occurring at the bone–implant interface can be altered by nanoscale modifications and can result in better treatment outcomes.