Background:Substance abusehave high degree of psychiatric comorbidities.The study of comorbidities can contribute in different ways for better understanding of the problems and management of patients with substance dependence.

Objectives: to assess the prevalence of psychiatric comorbidities among opioid dependent patients.

Material and Method:40 cases of opioid dependence who attended psychiatry opd of Gauhati Medical Collegewere selected based on ICD 10 criteria. The psychiatric comorbidities were assessed in them using MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW.

Result:In our study of 40 opioid dependent patients psychiatric comorbidities were found in25 (62.5%). The comorbidities were found to beMood disorders in 13(32.5%),antisocial personality disorder in 8 (20%) ,Generalized anxiety disorder in 3 (7.5%) and panic disorder in 1(2.5%).

Conclusion: From the present study we came to the conclusion that psychiatric comorbidities are common among opioid dependent patients.