IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-5-15343 Original Research Paper Significance of micronuclei score as a screening tool in cervical intraepithelial neoplasia and cervical cancer Banu Ranjini Sridharan Dr. Dr. Anita Ramdas Dr. May 2018 7 5 01 02 ABSTRACT

Objective : To compare and assess the score of micronuclei in a spectrum of non–neoplastic, pre–neoplastic lesions and invasive cancer of the cervix.

Materials and methods: In this retrospective study, we have assessed the micronuclei count in 48 cases in conventional pap smears. The smears were analysed by light microscopy under oil immersion (x 1000) .

Results: Mean ± SD [Median ( Min –max)] for microncleated  cell count  were as follows : Normal –  4.50 ± 2.070 [4.00 ( 2–9)  ], Inflammatory –  4.38 ± 2.669 [4.50 ( 1–8) ], Infections – 5.25 ± 2.121 [5.00 ( 2–8)],  LSIL–  7.75 ± 3.327 [8.00 ( 2–14)], HSIL –11.63 ±  8.193 [9.50 ( 2–28) ] and  SCC – 16.25 ±  4.027 [16.00 ( 11–24) ].

Conclusion: micronucleus counting  can be taken as a helpful screening tool in conjunction with conventional Pap test for screening of cervical cancer.