Objectives:

To study the efficacy of ramosetron  in prevention of post operative nausea and vomiting in females following abdominal hysterectomy under general anaethesia and to compare it with that of granisetron.

Methods:

In this randomized, double blind study, 80 female patients divided into two groups of 40 each received either 2 mg Granisetron or 0.3 mg Ramosetroni.v towards   the completion of surgery.Incidence of postoperative nausea and vomiting and requirement of rescue antiemetic was compared between the two groups at various intervals. The standardized anesthetics included isoflurane and nitrous oxide in oxygen.

Observations:

The difference in the incidence of nausea, vomiting and requirement of rescue antiemetic immediately after extubation, 0–6 hours and 6–12 hours after extubation was statistically insignificant (p>0.005), while as the difference in the incidence of nausea, vomiting and requirement of rescue antiemetic 12–18 hours and 18–24 hours after extubation was statistically significant (p<0.005). No clinically important adverse events due to the study drug were observed in any of the groups.

Conclusion:

Ramosetron was more effective than Granisetron for prevention of post–operative nausea and vomiting during 12 – 24 hours after anesthesia for abdominal hysterectomy under general anaesthesia.