Introduction: Hypothyroidism, the commonest form of hormonal dysfunction, is due to thyroid hormone deficiency or its impaired activity. Various electrolyte disturbances in association with hypothyroidism were observed in many studies

Objectives– To assess and analyse the alterations in the levels of serum calcium, magnesium and phosphorous and their relationship with T3, T4 and TSH in patients of hypothyroidism.

Material and Methods– We conducted a case control study were 120 known cases of hypothyroidism and 120 age and sex match controls were selected. Blood sample for analysis was collected from all the subjects and serum T3, T4, TSH, magnesium, calcium, sodium and phosphorous were estimated in all the subjects.

Results–The levels of calcium, sodium and potassium were significantly decreased in cases then controls.Serum phosphorous (p<0.0001) and magnesium(p<0.0001) were significantly increased among cases compared to controls.

Conclusion: A regular follow up of these serum minerals should be done in thyroid hormone deficiency which would be of great help in its management.