Background:Thyroid nodules are very frequently found and their prevalence steadily increases with age. They can be either benign or malignant. Solitary thyroid nodules (STN) have a high likelihood of being malignant.  They should be characterized properly for optimum management.

Aim:To know the incidence of malignancy in cases of solitary nodule thyroid.

Methods: A total of 100 cases were admitted and studied during period from August 2010 to November 2012 in Sri Venkateswara Medical College, Tirupathi. All patients with STN identified by ultrasonography were included. Pre–operatively, Fine Needle Aspiration Cytology (FNAC) were done and the results were compared post–operatively with histopathology.Results:Incidence of malignancy in STN was 19%. Incidence of solitary nodule was more common in females(72%) than males (18%) and mean age of presentation was between 20 and 50 years. Incidence of malignancy was more common in males than females.Conclusion: STN should be investigated thoroughly with a high index of suspicion because there was a high probability (19%) of malignancy.