Small round blue cell tumor is a very common diagnostic finding after intraoperative diagnostic procedures such as squash cytology or frozen section. After proper biopsy techniques, histopathological diagnosis and immunohistochemistry confirmation,a diagnosis of Esthesioneuroblastoma is established. Due to its aggressiveness and high recurrence rate, it is mandatory to diagnose this tumor as soon as possible. In our three year study period, only 3 cases of Esthesioneuroblastoma were reported in which extensive Immunohistochemistry panel played an important role to differentiate it from others and come to a conclusive diagnosis. These cases were first diagnosed through squash cytology as a small round blue cell tumor. Later it was confirmed as Esthesioneuroblastoma by histopathology and immunohistochemistry using synaptophysin, chromogranin, CD 56& CD 99. MIB–1 played an important role in grading of the tumor according to Hyam’s histological grading.