Background and objective– Laryngoscopy and tracheal intubation are of paramount importance during conduct of general anaesthesia. The common accompaniment of these procedures is sympathetic stimulation and hyperdynamic response.To compare Lignocaine and Clonidine in attenuation of pressor response to laryngoscopy and intubation  with respect to the following– Effect on cardiac rate,  Effect on blood pressure.

METHODOLOGY–All noninvasive monitoring was done. INDUCTION AND MAINTENANCE was done as per protocol.with drugs like glycopyrolate,midazolam,fentanyl,thiopentone.

Conclusion–we recommend Inj Lignocaine 1.5 mg/kg to be used more frequently as a premedication in patients undergoing  elective surgery under general anesthesia and we need to increase the dose of clonidine for  complete blunting of intubation response.