Birth defects are a significant cause of mortality and disability among infants and children under five years of age.Inadequate knowledge of antenatal women about these could affect timely management. The study was undertaken to assess the knowledge, attitude and practices of antenatal women related to congenital anomalies and association of knowledge with their sociodemographic profile. A cross–sectional observational study was conducted including400 antenatal women. A pre designed, pre tested, structured questionnaire was used to assess their knowledge attitude and practices. Most of the women had poor knowledge score and did not know that some birth defects are preventable. 65% women did not know about the gestational age permitted under MTP act. Improved knowledge, attitude and practices related to congenital anomalies would be helpful in reducing births with congenital anomaly and thus burden to family and society.