Megaloblastic anemia is one of the important causes of anemia.Megaloblastic anemia is not rare, but its different clinical manifestationsmakes difficult to diagnose. Apart from pallor, glossitis, paresthesia, hyper pigmentation, confusion and ataxia,jaundice is also one of theclinical features of megaloblastic anemia.Out of 42 megaloblastic anemia cases, 12 patients with jaundicewere selected for the study. It was found that there is an increase in the level of Sr. bilirubin, lactate dehydrogenase (LDH) and mean corpuscular volume (MCV) inmegaloblastic anemia.The study performed in this article reveals jaundice as one of variants clinical features of megaloblastic anemia.