Gestational diabetes mellitus(GDM) has serious ramifications on the offspring such as Hypoxemia, Visceromegaly, Perinatal mortality, Hyper bilirubinemia, Obesity, Hyperglycemia, reduced immune function and cognitive function. Gestational diabetes is known to effect placental metabolism, growth, and development. The maternal and fetal hyperglycaemia have an impact on the production of placental proteins. Concerns regarding these denouements are escalating rapidly in the developing countries, there is a need of deeper understanding pertaining to the pathophysiological, therapeutic and preventive measures of GDM. Lack of awareness among the patients is also responsible for fetal abnormalities caused by GDM. In this review we have given a brief account of Fetal Developmental Trajectory,Intrauterine exposure to gestational diabetes, Placental impairment and Modifications in materno–placental oxygen supply. At the end, we have noted the impact of Embryonic Amino Acid Metabolism during Early Pregnancy.