Introduction: Acid base imbalance is a common complication in severe infectious

disease including falciparum malaria. The aim of this study was to evaluate the acid base imbalance inmalaria.

Material and Methods: This descriptive observational study was carried out from March 2015 to Aug 2016 in department of medicine Gandhi medical college Bhopal. All malaria positive cases admitted in medical ward and who were willing to participate were enrolled the study and those patient who received i/v fluid before admission and associated with co morbid condition like copd acute exacerbation, diabetic ketoacidosis, chronic renal failure etc. Were excluded from the study.  ABG analysis was done by ESCHWELER COMBISYS II.

Results: Out of 100 malaria positive cases[P. Vivax(39), P. Falciparum(46), Mixed infection(15)] Metabolic acidosis and respiratory acidosis were observed as 17%, 3%, respectively and P. Falciparum had most common acid base

Imbalance[Metabolic.acidosis(12/46), Metabolic alkalosis(3/46), Respiratory acidosis(1/46)].

Conclusion: This study was aimed to assess acid base imbalance, associated with malaria .Most commonly observed acid base imbalance was metabolic acidosis which had a very high correlationwith falciparum malaria, other acid base imbalances common in decreasing order were metabolic alkalosisand respiratoryacidosis.