Background: Atherosclerosis of the coronary arteries causes Coronary artery disease (CAD) and is the leading cause of mortality and morbidity among patients with type 2 diabetes mellitus.Objective:To evaluate the role of adiponectin and hs–CRPin CAD with and without T2DM.Methods: Total 120 subjects (age group 25–70 years) of either sex were enrolled. The subjects were categorized into four groups i.e. Group I (30–Controls), Group II (30–DM with CAD), Group III (30–non–diabetic with CAD) and group IV (30–DM). Adiponectin and hs–CRP were estimated by ELISAand immune–turbidimetric method respectively. Results: The mean level of adiponectin was decreased whereas increase in level of hs–CRP in all study groups compared to controls and were significant (p ≤ 0.001).Conclusion:Due to alteration in the inflammatory markers in CAD, the early assessment of such markers can help to identify high risk patients.