BACKGROUND –The advent of MDR TB threatens to de–stabilize the Tuberculosis control programmes all over the globe. MATERIALS AND METHODS– It was a retrospective cohort study. Microsoft Excel 2007 was used to analyze medical records.RESULTS–Out of 113 patients under study, 68 (60.17%) patients were successfully treated (cured 50 [44.24%] + treatment completed 18 [15.92%]). 22(19.46%) patients died, 10 (8.84%) failed, 10 (8.84%) defaulted and 2 (1.76%) were transferred out to other sites. For the rest, treatment was discontinued or 1(0.88%) was shifted to XDR. 41 (36.28%) converted their sputum culture to negative (“initial favorable response”) after the intensive phase of therapy. CONCLUSION– The successful treatment rate is still low though higher than the WHO reported data of MDR–TB 2014 onwards. MDR–TB is a challenge which must be undertaken by judicious use of appropriate drugs, supervised individualized treatment and follow–up which constitute the key factors for successful management of these patients.