Introduction– Pharmacovigilance is science and activities relating to detection, assessment, understanding and prevention of adverse effects or any other drug related problem. This study focuses upon study of the awareness, attitude and practices of doctors, nurses and pharmacists towards adverse drug reaction reporting & monitoring in a tertiary care hospital. Methods– This is a cross–sectional study involving the use of a structured questionnaire for obtaining information related to knowledge, attitude and practices (KAP) of doctors, nurses and pharmacists towards adverse drug reaction reporting & monitoring. Participants were also asked about some suggestions to improve the adverse drug reaction reporting practice. Results– There is a significant lacuna in the existing knowledge, attitude and practice of health care professionals regarding ADR reporting. Majority of the participants felt the need of more help and coordination from institutional ADR monitoring centre for filling ADR forms. Conclusions– There is an inadequate knowledge and poor beliefs and practices in medical professionals regarding ADR reporting.