To improve the selection of an appropriate antimicrobial agent and to understand the clinical and microbiological characteristics of bacteremic Salmonella sp, a laboratory–based surveillance of blood culture positive Salmonella sp was conducted during two year period in a tertiary care hospital. The clinical profile and antibiotic usage were obtained from Hospital Information system and medical record department. 16649 patient’s blood samples received for blood culture and sensitivity test. Of these 501 (3.01%) patients’ blood yielded Salmonella sp (S.Typhi 385; S.ParatyphiA 116, a ratio of 3.32).  It was isolated throughout the year but peaked in April–May. Paediatric age group constitutes quarter of the burden of enteric fever. All patients presented with fever (100%), followed by pain abdomen (33%), vomiting (27%), diarrhoea (18%), constipation (4%), splenomegaly (30%) and hepatomegaly (20%). Complications were seen in 5% cases. No mortality was observed. The antimicrobial sensitivity of Ampicillin was 92%, Ceftriaxone 94%, Ciprofloxacin 39%, Levofloxacin 33%, Cotrimoxazole 88.2%, Chloramphenicol 87% and MDR observed in 4%. The most commonly used antibiotics were 3rd generation Cephalosporin. Enteric fever is a significant public health problem in Delhi. It is important to be aware of local antibiotic sensitivity pattern as limited options are available to commence the treatment empirically.