Malignant transformation of benign bone tumors is rare. Although chondrosarcoma may develop in patients with multiple enchondromatosis, this event rarely occurs in the hand. We report a case of chondrosarcoma (CS) in a 26–year–old patient secondary to multiple enchondromatosis in bilateral hands. It is crucial to diagnose malignant change in enchondroma to plan the appropriate management, keeping in mind the possibility of local recurrence and metastasis of secondary CS.