The attendant danger of hypertension and tachycardia observed during laryngoscopy and intubation, needs considerable attention to prevent their consequences such as arrhythmia and myocardial ischemia. In patients with cardiovascular disease these hemodynamic changes may lead to life threatening complications like acute heart failure, cerebrovascular accidents. The aim of our study is to evaluate the efficacy of IV dexmedetomidine premedication on attenuation of haemodynamic response (HR and MAP) to laryngoscopy and intubation.