Intern Doctors are potentially exposed to blood and body fluids (BBF) in the course of their work and therefore are at risk of infection with blood–borne pathogen. This article accessesprevalence of NSI and sharp injuries and compliance regarding universal safety precaution, barriers and difficulties faced. A hospital based cross–sectional Observational study carried out in Tertiary care hospital in Mumbai among 120 intern doctors posted in various ward over 2 months after ethics committee approval.Self–administrated Interview schedule was used for data collection. Overall Incidence of NSI was 23.3% (28). Most proportion being in “medicine and allied departments” (60.7%). Among casesreported, 92.9% took PEP treatment. The risk gradation was Fatigue (75%), Open bore needle use (64.3%), drawing blood sample (53%) and Needle recapping (19.3%). Strengthening the surveillance and compliance of guidelines will result in risk reduction.