Introduction:Septicemia by definitionis proliferation and multiplication of microorganism in the bloodand it is one of thecommoncausesofdeathinnon–coronaryIntensiveCareUnit.Itisacommoncauseofmorbidityandmortalityparticularlyincriticallyillpatients as well.Symptomsofsepticemiaincludetachycardia,tachypnea,fever,alteredtotalWBCcountsetc.Rapiddiagnosisofsepticemiaiscriticalinmanagementofpatients as sometimes death may be very imminent.Bloodcultureremainsthegoldstandardfordiagnosisofsepticemia butamajorlimitationisunavailabilityofresults rapidly as it takes approximately48hrs.Method: Present study was a retrospective study considering one year dataof patients admitted in a tertiary care hospital. Result: 90 out of 140 had Procalcitonin above normal reference range and amongthesepatientswithraisedprocalcitoninlevelbloodculturewerepositivein69patients.Conclusion:Study concluded that Procalcitonin is rapid marker, and has high sensitivity and specificity in detection of septicemia and correlate well with blood culture reports.