Backgroud –Biliary tract disease affects  significant number of population in the world. Over 95% of the biliary tract disease is due to cholelithiasis .This study has been undertaken to study the histological spectrum of changes seen in gall bladder removed for gall stones.The findings were mucosal hyperplasia, ulceration, inflammation ,fibrosis, metaplasia and carcinoma.

Material and method: 211 specimens of cholecystectomy performed for gall stone  were included in this study over a period of  24 months.

Result: There was female preponderance with  maximum cases in age group 41–50yrs .The most common histological finding were mucosal hyperplasia 74.46% inflammation78.19% ,RA sisuses70.28%and fibrosis 81.04%. Metaplastic changes (both pyloric and intestinal) were seen in 12.79% .Incidental Carcinoma was detected in five cholcystectomy specimens  removed for gall stones(2.36%).Other histological finding were mucosal ulceration 23.22%. and choleterolosis  2.36% .

Conclusion: Gall stone disease is common in age group of 41–50yrs with female preponderance.No age was exempt. Gall stone cause spectrum of histological changes in gall bladder mucosa most significant is metaplasia which can be precursor lesion for carcinomatous changes. Cholecystectomies done for gall stones can also harbour incidental  carcinomas which have poor prognosis.