Introduction :– Pseudomonas aeruginosais one of the most prevalent bacterial species, especially in the adult population. It is an ubiquitous and versatile human opportunistic pathogen and has implications on morbidity, mortality and healthcare costs both in hospitals and in the community.²

Objective :–Current studies was antimicrobial sensitivity profiles of P.aeruginosa are essential to find out the susceptibilities of this pathogen against commonly prescribed antibiotics in any health care facility.

Methods :– 150  strains of P.aeruginosa were isolated from different clinical specimens and fully characterized by standard bacteriological procedures. Antimicrobial susceptibility patterns of each isolate was carried out by the Kirby– Bauer disk diffusion method as per guidelines of CLSI.

Results: Majority of isolates of P.aeruginosa 102 (68.00%) were obtained from specimens of pus followed by wound swab and  urine. The isolated pathogens showed 100% sensitive to Polymyxin –B and Colistin. Least  sensitive to ciprofloxacin (12.5%).

Conclusion: The results confirmed the occurrence of drug resistant strains of P.aeruginosa. The encouraging finding was its sensitivity to Polymyxin–B and Colistin as an effective antibiotic for the treatment.It therefore calls for a very judicious, rational treatment regimens prescription by the physicians to limit the further spread of antimicrobial resistance among the P.aeruginosa strains.