In this era, there is need for new analgesics.Venlafaxine is an antidepressant and has antinociceptive effect. This study evaluatesanalgesic property of Venlafaxine and combination of subanalgesic doses of Aspirin and Venlafaxine in experimentally induced pain models in rats and mice and compared with standard drug Aspirin.Albino mice and wistarrats of either sex were included and were divided into 4 groups of six in each.Methods used to produce pain were chemical method(by intraperitoneal injection of 0.6%&0.1% of acetic acid in rats and mice), and radiant heat method(by analgesiometer).Results obtained from tail flick response (thermal method) in rats and mice and Writhing test (chemical method) in mice  showed that Venlafaxine and aspirin combination has more antinociceptive effect when compared with individual drugs Aspirin and venlafaxine.Venlafaxine at 10mg/kg dose has shown to produce antinociceptive effect, which is less than the antinociceptive effect of standard drug Aspirin.