C–reactive protein (CRP), an acute–phase protein synthesized by the liver following stimulus by various cytokines markedly increase within hours after infection or inflammation.

A prospective cohort study was conducted in a Emergence medical ward in a Hamidiahospital, Bhopal (M.P.) India .Aim of study was to study the association between early serum CRP concentrations and the development of organ failure .patient were divided in 3 groups based on crp at time of admission. in gp 1 crp<1mg/dl, gp2 1–10mg/dl &gp 3 >10mg/dl.Cardiovascular, respiratory , renal and coagulation failure statistically significant increased in group 3 than 1 at time of admission(p<.05). We have evaluated that theiris  correlation of CRP levels with organ failure after ICU admission in a heterogeneous group of ICU patients with different disease.