IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-7-15963 Original Research Paper A study to show the effect of Vitamin D3 on efficacy of Anti-tubercular therapy (ATT) / Directly Observed Treatment, Short Course (DOTS) regimen. Suneet Jindal Dr. July 2018 7 7 01 02 ABSTRACT

 INTRODUCTION : Pulmonary tuberculosis is one of the largest causes of deaths due to infections worldwide. WHO recognizes India as one of

the 22 high–burden countries (HBC‘s) that account for about 80% of the world‘s TB cases. The evidence for role of Vitamin D3 on the course of
tubercular disease is inconclusive and different studies show both favorable and unfavorable responses. No data is available on dose–dependent
effects of vitamin D3 on mycobacterial activity.
MATERIAL AND METHODS: A prospective, randomized, interventional study of 90 days duration was conducted by dividing 60 newly
diagnosed sputum positive pulmonary tuberculosis Category I patients of either sex with age ≥16 years in two groups i.e
Group A receiving standard Anti–tubercular therapy in combination with
Vitamin D3 600,000IU intramuscularly on Day 0, 30 and 60 and Group B receiving standard Anti–tubercular therapy (DOTS regime) alone.
RESULTS: Out of 60 subjects enrolled in the present study, 39 (65%) patients were from urban, and 21 (35%) patients were from rural population.
All the patients enrolled in the study belonged to Below Poverty Line (BPL) group. In Group A and Group B, there was statistically significant
increase in mean difference in body weight at 30, 60 and 90 days from the baseline within the groups. No difference was found in 0 to 90 days
among Group A and Group B. There was statistically significant increase in Vitamin D levels in Group A only on 90 days. At 90 days, there was
significant difference in Vitamin D levels between Group A and Group B.