Hashimoto’s thyroiditis is most common form of autoimmune thyroiditis and the second most common thyroid lesion next to goiter.  Middle aged women are most commonly affected and the commonest presentation is hypothyroidism with diffuse enlargement of thyroid gland. The purpose of this study is to review the cytomorphologic spectrum of HT and to correlate with clinical presentation, thyroid function tests and antibody profile. This is a prospective study conducted in the Department of Pathology, KIMS, Bhubaneswar, from January 2016 to December 2017. 115 cases of Hashimoto’s thyroiditis were included in this study. Cytomorphologic features were reviewed, graded & were correlated with clinical presentation, anti–thyroid peroxidase (anti–TPO) antibodies and TFT.Out of total 115 cases, 3.5% were males and 96.5% were females. Most common age group was 31– 40yrs. 80 cases (69.6%), 22 cases (19.1%) and 13 cases (11.3%) had diffuse, nodular & solitary thyroid swellings respectively. Hypothyroidism was the commonest finding (68 cases, 59.1%). 32 cases (27.4%%), 65 cases (56.5%) and 18 cases (16.1%) were of grade I, grade II& grade III HT respectively. Anti–TPO was raised in 85.4%, 95.3% and 98.5% cases of Grade I, Grade II & Grade III cases respectively. A multidisciplinary approach including clinical, radiological, biochemical and cytological parameters should be utilized for detecting subclinical hypothyroid state and provide a guide to therapy.