The GI system consists of the GI tract and its associated organs and glands. Factors outside the GI tract can influence its functioning. Psychological, emotional factors and physical factors such as dietary intake, ingestion of alcohol and caffeine–containing products, cigarette smoking, poor sleep and fatigue may also affect GI function.The increase rate of disease is due to stress and life style patterns in this industrialized world, which are modifiable. A study to evaluate the effectiveness of STP regarding knowledge on healthy life style practices on prevention of peptic ulcer among employees of railway carriage repair workshop at Bhubaneswar.A quasi–experimentalwith one–group pretest posttest design is adopted. The study is conducted at Railway Carriage Repair Workshop at Bhubaneswar. Probability simple random sampling technique is used with 60 railway employees. The pretest knowledge on healthy life style practices on prevention of peptic ulcer out of 60 sample, 10 (17%) had poor knowledge, 50 (83%) had moderate knowledge and none of them had excellent knowledge. In the posttest, 02 (3%) had average knowledge, 58 (97%) had excellent knowledge and none of them in the poor knowledge. Regarding effectiveness of STP, Overall knowledge score obtained by the employees in the pre–test is 62.3% and posttest score is 92.42%. The overall improvement is 30.12% with t value 1.98. This is highly significant at P<0.001 level.The findings of the study also revealed that there is a significant association between the posttest knowledge and demographic variables of age, educational status,  income, religion, area of living, working department in workshop, period of service and dietary habits at P<0.05 level. The study concluded that the STP is found to be very effective in improving the knowledge of employees on healthy life style practices on prevention of peptic ulcer.