IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-7-16003 Original Research Paper Clinical profile and outcomes of acute lymphoblastic leukaemia in children; an experience from a newly established pediatric oncology unit from eastern zone of India. P Panda Dr. Mrutunjay Dash Dr. Sourav K Mishra Dr. July 2018 7 7 01 02 ABSTRACT

Objective:One third of all childhood cancers are leukaemia; approximately 10,000 new cases are diagnosed in India each year. To describe the clinical characteristics and outcomes of paediatric acute lymphoblastic leukemia (ALL).  Material and Methods:  Medical records of pediatric ALL diagnosed between April 2015–March 2018 were reviewed using a custom data collection sheet. Results: Seventy one cases were enrolled;median age 4 years, 52% male.Common clinical findings at presentation were fever(77%), hepatosplenomegaly(70%), lymphadenopathy (37%) and pallor(30%). Ninety two percent patients achieved complete hematologic remission. Infection was the most common cause of mortality. Event–free survival and overall survival at 2 years were 67%and 79% respectively. Conclusion:  Clinical characteristics are similar to those reported in the literature. Cytogenetic study (conventional karyotyping and FISH analysis) needs to be monitored for a better result. Chemotherapy regimen used appears to be effective, tolerable and feasible.