Plant extracts which may be used as antimicrobial drug therapy is a hidden field of research.The use of traditional herbal medicine is an important source for the treatment of illness and it represents one of the most sought after area of research today. This study was undertaken to Houttuyniacordata  on standard  and resistant microorganism strains of Pseudomonas  isolated from clinical samples. Effect of methanolic extract of Hyouttuniacordata on standard strain showing a Mean of 14.14mm +/– 0.936 SEM and resistant strains showing mean of 8.15mm +/– 1.19 SEM in 20 clinical isolates. The result of this study showed methanolic extract of Hyouttuniachordata showed significant inhibition against standard strain of Pseudomonas although less activity against resistant strainsof the same microorganism.