Background: Staphylococcus aureus (S. aureus) isolate from the urinary tract of most patients are becoming resistant to commonly used antibiotics. This pose a challenge for timely treatment. The present study was conducted to determine the resistance profile of the S. aureus isolates from Patients with Urinary Tract Infections (UTIs) attending Muhammadu Shuwa Memorial Hospital Maiduguri. 

Methods: Midstream urine specimens of UTIs symptomatic patients from Muhammadu Shuwa Memorial Hospital, Maiduguri were collected, cultured, and screened for common pathogens using standard microbiological protocols. The antimicrobial susceptibility of identified S. aureus strains was evaluated using standard agar disc diffusion techniques.

Results: A total of 50 S. aureus strains were identified. None of the S. aureus isolates were susceptible to Amoxicillin (0%) and Ceftriaxone (0%); they showed 2% susceptibility to Co–trimoxazole and Erythromycin each, 42% to Chloramphenicol, 44% to Ciprofloxacin, 54% to Pefloxacin, 60% to Streptomycin, 72% to Ofloxacin, and 82% to Gentamycin. The isolates were commonly resistant to 9 (90%) of the ten classes of antimicrobial agents used in this study and all the isolates were multidrug–resistant.

Conclusion: There is need for continuous investigations on antimicrobial resistance profile of UTI for proper empiric treatment of uncomplicated UTIs. Thus, the need to adopt new strategies in the control of antibiotic resistance in the studied environment cannot be overemphasized.