Background :Deliberate termination of pregnancy either by medical or by surgical method before the viability of the fetus is called Induction of abortion. World Health Organization, define abortion as pregnancy termination before 20 weeks’ gestation or with a fetus born weighing <500 gm. Rubber catheter has been widely used in India as an abortifacient, as mentioned in a case series of 200 midtrimester MTPs in the early eighties.

Methodology: This prospective comparative study was conducted on 50 female patients having pregnancy of 13–20 weeks desirous of MTP coming to the hospital were divided into 2 groups alternatively. Each group had 25 patients each. Group A–Vaginal tablets Misoprost (400ug) was used every 4 hrly. Group B–Vaginal tablets Misoprost (400ug) was used along with intrauterine extraamniotic rubber catheter placement.

Result :In group A, 11 patients ( 44%) had retained products of conception. In group B, only 3 patients (12%) had retained POC, rest expelled the products completely. The “p” value was 0.0255. 100% of group B patients aborted within 12 hrs whereas only 3% patients in Group A aborted within 12 hrs.”P” value was 0.0001.

Conclusion: The combined use of vaginal Misoprost and extra amniotic rubber catheter is more effective, well tolerated, less expensive and superior to vaginal Misoprost alone in second trimester MTP up to 20weeks.