Background: Cancer has recently become one of the most obsessing issues in the world, since both its incidence and impact on world economy has become enormously huge. Breast cancer is potentially life threatening malignancy that develops in one or both breasts.

Aim:To estimate the serum level of trace elements copper, zinc  in female which are newly

diagnosed with breast cancerTo establish any correlation between level of trace elements in severity ofbreast cancer disease.

Methods : Copper and zinc was estimated by di Br–PAESA method  and 5–Brom–PAPS Johnsen and R.Eliasson (1987) on semi auto analyser and  read at 580 nm and 570 nm.

Results : Serum levels of copperan d  zinc in breast cancer patientsuggests a strong positive and negative correlation.

Conclusion : serum levels of these trace element can be use  as a marker for early diagnosis of breast cancer.