Metformin is the most widely prescribed first line anti diabetic drug for diabetes worldwide.Antibacterial property had been identified first& intended to treat infections but at the same time it wasnoticed that metformin "lowered the blood sugar and was non toxic, so that hypoglycaemic effect of metformin became a one of the thrust area of research.

The treatment of microbial infections withanti–microbial drugs became a serious global health issue due to development of antimicrobial drug resistance.  In this complexity new drugs related to antibiotic & non antibiotic class or new drug combinations may be the solution against development of resistance in serious microbial infectious diseases.Hypoglycemic, Antihistamines, antipsychotics, Antihypertensive and Local anesthetics had been believed to have powerful antibacterial activity. Hence drugs belongs to respective classes had been grouped together and entitled as “Non– antibiotics”. Inpresent study an oral hypoglycaemic drug called metformin antimicrobial activity had been analyzed and the results show that metformin is active against P. aeruginosa. Metformin as non–antibiotic antibacterial drug may reduce the morbidity in diabetic patients.