Aim:To assess the quality of life and performance in Oral submucous fibrosis (OSMF) patients who are undergoing a treatment regime and being followed up for 3 months using validated specific questionnaire.

Material and methods: 30patients receiving treatment in the department of oral medicine and radiology who had a clinical and established histopathologicaldiagnosis of oral submucous fibrosis were enrolled for the study and were assessed byusing standardized measures of quality of life (QOL).

Result:Older patients—those older than age 35 years—reported significantly lower QOL (p = 0.015).Further comparison of age with different domains revealed a significantly lower QOL in the domain of social and emotional status. Significant age–related differences in QOL were not observed in the other domains. Men reported significantly better oral health–related QOL than women in pain and functional limitation.

Conclusion: Clinical evaluation of COMDQ, by including dentists and physicians, may give information about the cause, can aid in determining potential treatments, and can also provide clues about the prognosis but may not directly reflect the resulting level of impairment.