Skin is considered to be the best covering of Human body. Because it interfaces with the environment, it plays an important immunityrole in protecting the body against pathogens^[1]. Skin performs many important and crucial functions of body, therefore loss of skin results in many complications. Because of which it is imperative to cover skin loss at the earliest. There are many options available to cover skin loss and one of the best and convenient methods is Split skin Grafting (SSG). However, SSG fails, if not fixed. If not fixed, mobilization of graft may occur leading to failed revascularization and then necrosis of graft. Therefore, it is mandatory to fix the split skin graft to donor site for its survival. Many techniques and materials have been used for fixation of split skin graft. Each has its merit and demerit. In this article, we present comparative study of effectiveness of fixation of SSG with sutures versus Cyanoacrylate tissue adhesive.