The aim of this study was to investigate the aqueous leaf extracts of Anisomeles Malabarica and synthesized silver nanoparticles using aqueous leaf extract extract of plant parts to produce extremely secure silver nanoparticles in water. The results recorded from UV–vis spectrum, scanning electron microscopy, X–ray diffraction, and Fourier transform infrared support the biosynthesis and characterization of silver nanoparticles. The maximum efficacy was observed in crude methanol, aqueous, and synthesized silver nanoparticles. The results shows that the leaf of methanol extracts of Anisomeles Malabarica and bio synthesis of silver nanoparticles have the potential to be used as an ideal eco–friendly approach  for the control of anti bacterial activity.